解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Melatonin synthesis is disordered in patients with Alzheimer's disease (AD). To determine the role of melatonin in the pathogenesis of AD, suitable animal models are needed. The OXYS rats are an experimental model of accelerated senescence that has also been proposed as a spontaneous rat model of AD-like pathology. In...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-014-9547-7
更新日期:2015-06-01 00:00:00
abstract::In C. elegans, mutations in the conserved insulin/IGF-1 signaling (IIS) pathway lead to a robust extension in lifespan, improved late life health, and protection from age-related disease. These effects are mediated by the FoxO transcription factor DAF-16 which lies downstream of the IIS kinase cascade. Identifying and...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-014-9527-y
更新日期:2015-04-01 00:00:00
abstract::Dietary restriction (DR) exerts significant beneficial effects in terms of aging and age-related diseases in many organisms including humans. The present study aimed to examine the influence of long-term DR on the BDNF system at the transcriptional and translational levels in the cortex and hippocampus of middle-aged ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-014-9537-9
更新日期:2015-02-01 00:00:00
abstract::Calorie restriction (CR) extends lifespan in a remarkable range of organisms. However, the mechanisms of CR related to the longevity effects are not fully elucidated to date. Using human fibroblast Hs68 (Hs68) cells cultured at a lower level of medium glucose (i.e., glucose restriction; GR) to mimic CR, we investigate...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-014-9528-x
更新日期:2015-02-01 00:00:00
abstract::Aging process or senescence affects the expression of a wide range of phenotypic traits throughout the life span of organisms. These traits often show modular, synergistic, and even antagonistic relationships, and are also influenced by genomic, developmental, physiological and environmental factors. The cardiovascula...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-013-9486-8
更新日期:2014-04-01 00:00:00
abstract::Oxidative stress caused by reactive oxygen species is proposed to cause age related muscle wasting (sarcopenia). Reversible oxidation of protein thiols by reactive oxygen species can affect protein function, so we evaluated whether muscle wasting in normal aging was associated with a pervasive increase in reversible o...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-013-9483-y
更新日期:2014-02-01 00:00:00
abstract::Chronic oxidative stress plays a central role in the pathogenesis of many diseases, including HIV-1 associated disorders. Concomitantly with the decline of endogenous antioxidant systems, it was reported that HIV-1-related proteins increase the production of radical species in cells and tissues that are not directly i...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-014-9511-6
更新日期:2014-01-01 00:00:00
abstract::There is a viewpoint that suppression of the proliferative capacity of cells and impairment of the regeneration of tissues and organs in aging are a consequence of specially arisen during evolution mechanisms that reduce the risk of malignant transformation and, thus, protect against cancer. We believe that the restri...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-013-9468-x
更新日期:2013-12-01 00:00:00
abstract::After reaching adulthood, orderly repair is probably one of the most important mechanisms throughout lifetime. Regular wound healing after an injury consists of a well-ordered sequence of overlapping phases of repair and essentially repeats the complex process of organ development. Organ failure in the ageing organism...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-013-9453-4
更新日期:2013-12-01 00:00:00
abstract::Age is the principal nonmodifiable risk factor for stroke. Over the past 10 years, suitable models for stroke in aged rats have been established. At genetic and cellular level there are significant differences in behavioral, cytological and genomics responses to injury in old animals as compared with the young ones. B...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-013-9465-0
更新日期:2013-12-01 00:00:00
abstract::Two sibling Drosophila species dramatically divergent in longevity, Drosophila buzzatii and D. koepferae, were examined for possible effects of both developmental culture medium and dietary composition (DC) on longevity. Longevity was greatly increased in the longer lived D. buzzatii when flies were reared and fed on ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-013-9441-8
更新日期:2013-08-01 00:00:00
abstract::Human ageing is accompanied with deterioration in endocrine functions the most notable and well characterized of which being the decrease in the production of sex hormones. Current research literature suggests that low sex hormone concentration may be among the key mechanism for sarcopenia and muscle weakness. Within ...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-013-9425-8
更新日期:2013-06-01 00:00:00
abstract::Senescence evolved because selection pressure declines with age. However, to explain senescence it does not suffice to demonstrate that selection pressure declines. It is also necessary to postulate biological mechanisms that lead to a deteriorated state of the organism at high ages, but not before. This has lead to t...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9410-7
更新日期:2013-02-01 00:00:00
abstract::Glycolysis and oxidative phosphorylation (OxPhos) are the two major mechanisms involved in brain energetics. In this article we propose that the sporadic forms of Alzheimer's disease (AD) are driven by age-related damage to macromolecules and organelles which results in the following series of dynamic processes. (1) M...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9403-6
更新日期:2012-12-01 00:00:00
abstract::Previously, extremely low, nanomolar concentrations of the mitochondria-targeted plastoquinone derivative SkQ1 (10-(6'-plastoquinonyl) decyltriphenylphosphonium) were shown to prolong the lifespan of male and female Drosophila melanogaster by about 10 % (Anisimov et al., Biochemistry (Moscow) 73:1329-1342, 2008). Usin...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9404-5
更新日期:2012-12-01 00:00:00
abstract::There are currently no reliable biomarkers of ageing. A biomarker should indicate biological age, that is, the amount of an animal's total lifespan it has lived and, therefore, the amount of time it has remaining. Some potential biomarkers cannot be validated as their measurement involves harm or death of the animal, ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9393-4
更新日期:2012-10-01 00:00:00
abstract::Impaired sarcoplasmic reticulum (SR) function has been associated with reduced muscle force generation and locomotor function in aging animals. This study was conducted to determine the extent to which aging increased SR stress markers in male rats, and the extent to which volitional exercise affected them. We harvest...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9399-y
更新日期:2012-10-01 00:00:00
abstract::For a period of 6-15 days prior to death, the fecundity and virility of Drosophila melanogaster fall significantly below those of same-aged flies that are not near death. It is likely that other aspects of physiology may decline during this period. This study attempts to document changes in two physiological character...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9398-z
更新日期:2012-10-01 00:00:00
abstract::It is known that a global decrease in food ingestion (dietary restriction, DR) lowers mitochondrial ROS generation (mitROS) and oxidative stress in young immature rats. This seems to be caused by the decreased methionine ingestion of DR animals. This is interesting since isocaloric methionine restriction in the diet (...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-012-9384-5
更新日期:2012-08-01 00:00:00
abstract::Wound healing (WH) is a fundamental biological process. Is it associated with a longevity or aging phenotype? In an attempt to answer this question, we compared the established mouse models with genetically modified life span and also an altered rate of WH in the skin. Our analysis showed that the rate of skin WH in a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-011-9343-6
更新日期:2011-12-01 00:00:00
abstract::Sarcopenia, defined as the age-related loss of muscle mass, subsequently has a negative effect on strength, metabolic rate and functionality leading to a reduced quality of life. With the projected increase in life expectancy, the incidence of muscle loss may rise and further drain the health care system, with greater...
journal_title:Biogerontology
pub_type: 杂志文章,评审
doi:10.1007/s10522-011-9327-6
更新日期:2011-08-01 00:00:00
abstract::Adult stem cells are known to have a finite replication potential. Muscle biopsy-derived human satellite cells (SCs) were grown at different passages and differentiated to human myotubes in culture to analyze the functional state of various carbohydrate and lipid metabolic pathways. As the proliferative potential of m...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-011-9336-5
更新日期:2011-08-01 00:00:00
abstract::Inflammation is an underlying basis for the molecular alterations that link aging and age-related pathological processes. In a previous study, we found that secretory phospholipase A(2) (sPLA(2)) induced cellular senescence in human dermal fibroblasts (HDFs). To further investigate the association of inflammation with...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9318-z
更新日期:2011-06-01 00:00:00
abstract::Small sample size of genetic data is often a limiting factor for desirable accuracy of estimated genetic effects on age-specific risks and survival. Longitudinal non-genetic data containing information on survival or disease onsets of study participants for whom the genetic data were not collected may provide an addit...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9316-1
更新日期:2011-04-01 00:00:00
abstract::The human immune system, especially the adaptive branch, substantially declines with ageing. Several distinct immunosenescent events have already been described, yet data regarding to age-associated baseline alterations in immune cell function is limited. Therefore, by using the TaqMan Human Immune Arrays we conducted...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9274-7
更新日期:2010-12-01 00:00:00
abstract::The pivotal role played by zinc-gene interaction in affecting the inflammatory response mediated by IL-6 in ageing, successful ageing (nonagenarians) and the most common age-related diseases is now recognized. Contradictory data emerging from association studies of IL-6 polymorphisms with longevity and chronic age-rel...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9276-5
更新日期:2010-10-01 00:00:00
abstract::Aim of this study was to investigate whether the polymorphic ADA (Adenosine Deaminase, EC 3.5.4.4) gene, which determines the cellular level of adenosine and plays a crucial role in the regulation of the immune system and in the control of metabolic rates, is involved in longevity. 884 unrelated healthy individuals (a...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9266-7
更新日期:2010-08-01 00:00:00
abstract::Hundreds of genes and miRNAs have been identified as being involved in the determination of longevity, aging patterns and in the development of age-related diseases (ARDs). The interplay between these genes as well as the role of miRNAs in the context of protein-protein interaction networks has as yet been poorly addr...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9265-8
更新日期:2010-08-01 00:00:00
abstract::Adipose tissue plays a pivotal role in ageing and longevity; many studies, both human and animal, have focussed on the effects of food limitation. Here we present a new model based on striking differences between two 'normal' inbred strains of albino Wistar rats the Charles River (CR) and Harlan Olac (HO) that have ma...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-010-9271-x
更新日期:2010-08-01 00:00:00
abstract::Associations have been reported between plasma Cu and Zn levels and the incidence of the most important age-related diseases. Previously proposed methods of using plasma Cu/Zn as a predictor of all-cause mortality have been derived from populations in which old and very old subjects were underrepresented. The purpose ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9251-1
更新日期:2010-06-01 00:00:00
abstract::Numerous reports implicate increased oxidative stress in the functional and structural changes occurring in the brain and other organs as a part of the normal aging process. Dietary restriction (DR) has long been shown to be life-prolonging intervention in several species. This study was aimed to assess the potential ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9240-4
更新日期:2010-04-01 00:00:00
abstract::It has been postulated that the presence of parasites causing high extrinsic mortality may trigger an inducible acceleration of the host aging. We tested this hypothesis using isogenic populations of Caenorhabditis elegans nematodes and different Escherichia coli strains. When exposed to pathogenic bacteria, nematodes...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9228-0
更新日期:2010-02-01 00:00:00
abstract::Histone post-translational modifications (PTMs) are involved in diverse biological processes and methylation was regarded as a long-term epigenetic mark. Though aging represented one of the major risk factors for neurodegenerative diseases, no systematic investigations had correlated the patterns of histone PTMs in th...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9231-5
更新日期:2010-02-01 00:00:00
abstract::During reproductive aging female rats enter an anovulatory state of persistent estrus (PE). In an animal model of reinstatement of estrus cyclicity in middle-aged PE rats we injected the animals with progesterone (0.5 mg progesterone/kg body weight) at 12:00 for 4 days whereas control animals received corn oil injecti...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9230-6
更新日期:2010-02-01 00:00:00
abstract::The effects of oxidative stress (OS) on the rat erythrocytes (RBCs) that were fractionated on the percoll/BSA gradient into young and old cells were studied to find out if the altered Na+/H+ and Cl⁻/ HCO3⁻ antiporters and in turn the intracellular pH (pHi) could act as one of the promoters of cell death. Old cells wer...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-009-9212-8
更新日期:2009-12-01 00:00:00
abstract::Oxidative damage has been proposed as an important factor in the progression of pathological and non-pathological age-related functional declines. Here, we examine functional deterioration in short-lived flies mutant for the mitochondrial antioxidant Manganese Superoxide Dismutase (Sod2). We find that the decline of s...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9210-2
更新日期:2009-10-01 00:00:00
abstract::The nematode Caenorhabditis elegans responds to flavonoid-rich diets with improved health and longevity. The precise mechanism(s) responsible for this remains to be identified, but is believed to be linked to the highly antioxidative properties of flavonoids. This study provides a dissection of lifespan modulation by ...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9199-6
更新日期:2009-10-01 00:00:00
abstract::Lung injuries are generally more serious and cause high mortality in aged humans and animals. Heme oxygenase-1 (HO-1) is known to be readily inducible in alveolar macrophages (AMs) and airway epithelial cells to confer cytoprotection against oxidative stress. We thus investigated whether aging impairs the stress-induc...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9164-4
更新日期:2009-04-01 00:00:00
abstract::In this study, we have assessed the impact of vitamin E and exercise on acquisition and retention of spatial memory for a given task in aging rats, using a T-maze. Acetylcholine esterase (AChE) and cholineacetyl transferase (ChAT) activities and acetylcholine (ACh) were measured in the cerebral cortex (CC) of male Wis...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9154-6
更新日期:2009-02-01 00:00:00
abstract::Prophylaxis with vaccines is important in geriatrics as, apart from specific protection, it reduces incidence of potentially fatal infectious complications and exacerbations of existing medical conditions. Post-vaccination protection depends on immunity and therefore markers of immune status could be used to predict e...
journal_title:Biogerontology
pub_type: 杂志文章
doi:10.1007/s10522-008-9155-5
更新日期:2009-02-01 00:00:00